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The release of these cytokines not only exacerbates neuroinflammation but also impacts synaptic plasticity and neuronal survival, leading to cognitive deficits and emotional disturbances commonly associated with depression (Liu et al

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Nat Rev Mol Cell Biol 14:269282 Mladineo I, Block BA (2009) Expression of Hsp70, Na+/K+ ATP-ase, HIF-1, IL-1 and TNF- in captive Pacific bluefin tuna (Thunnus orientalis) after chronic warm and cold exposure